There is a great urgency to address biodiversity loss and chemicals and waste pollution. These global challenges are intertwined in many ways. Pollution is identified as one of the main drivers of biodiversity loss. Therefore, it is important to look at these challenges and solutions in a synergistic way in order to address them effectively. Efforts to date have mainly focused on cooperation and synergies within the same thematic cluster. This review looks at the opportunities that may exist for working across thematic clusters, specifically focusing on strengthening collaboration and coordination between biodiversity and chemicals and waste clusters. The review provides options for action that can help implementation in particular at the national level, but also at the regional and global levels through enhancement of collaboration between biodiversity and chemicals and waste clusters.