Per- and polyfluoroalkyl substances (PFASs) are a large group of substances that have been widely used in articles since many years. They are found wherever extreme conditions prevail and particularly high demands are placed on materials. Their use spans over many different sectors ranging from fire-fighting foams to the manufacture of everyday articles like water-repellent outdoor jackets or stain-proofing agents.On the other side, PFASs are not easily degradable and can remain in the environment for decades. In addition, the use of PFASs has raised human and environmental concerns. In Europe, some PFASs are therefore classified as persistent, bioaccumulative and toxic (PBT) and very persistent and very bioaccumulative (vPvB) under the REACH Regulation. The following report provides an overview of currently available analytical methods for PFASs in different matrices.